Tae Song Kim received his Ph.D. degree in the department of materials science and engineering from the Korea Advanced Institute of Science and Technology (KAIST) in 1993. He worked as a Postdoctoral Research Associate in the Department of Electrical and Computer Engineering of Univ. of Minnesota in the USA (1998 - 1999). In 1994, he joined in materials research division of the Korea Institute of Science and Technology (KIST) where he started as a senior researcher, and then served as the Head of Microsystem Research Center (2000 - 2004). He also served as the Head of Intelligent Microsystem Center, where he organized and directed the Korean government research program “21 Century Frontier Intelligent Microsystems Program” from 2004 to 2010. In 2009, he served as conference chair of the 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS) in Jeju, Korea, and served as President of Korean BioChip Society (2011) and Micro & Nano Systems Society (2012). Currently, he serves as the Head of Micro Nano Fab Center in KIST. He is the co-author of 2 book chapters, 140 patents, and more than 120 peer-reviewed scientific papers in the field of miniaturized devices and systems, including nanobiotechnology, BioMEMS as well as lab-on-a-chip.
New Sensing Platform : 3D Lipid Bilayer Structure Arrays Fabricated on Si Substrates:
There have been many approaches using artificial membranes to explore the ion channels of cell membranes. In particular, sensory organ-related neurons are composed of many channels, which have connection to a three-dimensional cellular structure of sensory organ with a wider surface area to enhance sensory activity. Recently, the channel structure is revealed with Cryo-EM (Electron Microscopy), which has an improved resolution, but single channel recording is absolutely necessary to study the structure and function of the actual channel by using artificial cell membranes. Our group has been studying how to manufacture 3D FLB (3D free-standing lipid bilayer) arrays similar to real cells on solid substrates in order to solve the structural and functional problems of conventional suspended lipid bilayer membranes (BLMs). In this presentation, I will present 3D FLB fabrication and their sealing mechanism by the control of the electric field during the electroforming fabrication of 3D FLB, and also the human Serotonin receptors, 5HT3a, were reconstituted to the 3D FLB membrane for proving 3D FLB as a new sensing platform by comparing to planar BLM.